Our Story

We’re a different kind of biotech company.
And we’re here to make a difference

At Prometheus Biosciences, we aim to transform the paradigm of patient care with a proprietary precision-based approach to IBD and immune-mediated diseases. By harnessing the power of machine learning and leveraging the world’s most comprehensive collection of IBD patient data.

We’re not just changing the game. We’re changing lives. With the promise of targeted treatments.

The story of Prometheus Biosciences

It all started more than 20 years ago at Cedars-Sinai Medical Center where one of our founders, IBD luminary Dr. Stephan Targan, began building the IBD biobank. He recognized the potential of pairing IBD patient bio-samples with longitudinal clinical data—and this research led to the discovery of TL1A, the target of our lead program.

Dr. Stephan Targan.

Dr. Stephan Targan

Cedars Sinai logo.

Dr. Dermot McGovern.

Dr. Dermot McGovern

Dr. Janine Bilsborough.

Dr. Janine Bilsborough

The IBD biobank continued to evolve under the guidance of Dr. Dermot McGovern, who provided key genetics and computational expertise. Dr. Janine Bilsborough brought biotech and industry expertise, and spearheaded enhanced approaches to translating the learnings gleaned from the biobank into novel therapeutic strategies.

In 2016, with significant investment and the support of Cedars-Sinai’s Technology Transfer Office led by Jim Laur, the founders partnered with serial entrepreneur Scott Glenn to form a new company. The goal: to capitalize on their vision, the first precision medicine approach to IBD. Initially named Precision IBD, the company later became Prometheus Biosciences.

Cedars-Sinai and their exceptional IBD team remain close partners and collaborators, as we continue to develop new medicines for IBD and beyond.

Jim Laur.

Jim Laur

Scott Glenn.

Scott Glenn

Dr. Tadataka "Tachi" Yamada.

Tadataka (Tachi)
Yamada, M.D., KBE

In 2018, Prometheus Biosciences was fortunate to attract industry titan Dr. Tadataka “Tachi” Yamada to serve as Chairman of our Board of Directors, a position he held until his untimely passing in August 2021. Dr. Yamada brought immense drug development insights from his prior roles as Chief Medical and Scientific Officer at Takeda Pharmaceuticals, President of the Bill & Melinda Gates Foundation, and Board Director for numerous biotechnology organizations.

Our team will always remember the immeasurable contributions that Dr. Yamada has made to our organization–and to our lives. We carry on the important work of bringing precision medicine to immune-mediated diseases as a tribute to his memory.

See our mission